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KMID : 1144320210530040802
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감염과 화학요법
2021 Volume.53 No. 4 p.802 ~ p.807
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A Case of Human Immunodeficiency Virus-triggered Hemophagocytic Lymphohistocytosis Presenting with Severe Bleeding Tendency
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Kim Bong-Young
Choi Yeon-Woo
Pai Hyun-Joo
Kim Ji-Eun
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Abstract
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Human immunodeficiency virus (HIV) is one of the less common triggers of secondary hemophagocytic lymphohistiocytosis (HLH) in which coagulation disorder is a frequent manifestation. Here, we present a case of HIV-triggered secondary HLH presenting with severe bleeding tendency and fever. Despite high-dose dexamethasone infusion (10 mg/body surface area/day), progressive disseminated intravascular coagulation and thrombocytopenia resulted in massive hemathochezia: the bleeding episode ceased after endoscopic hemoclipping. After then, he took a highly-active antiretroviral therapy (HAART). Eventually, body temperature and overall laboratory findings normalized in response to HAART. Clinicians should not overlook HIV infection as a possible trigger of secondary HLH. In such cases, HAART is the core treatment.
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KEYWORD
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Human immunodeficiency virus, Acquired immune deficiency syndrome, Antiviral
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